环形透热切除术术后使用常规抗生素会降低发病率吗？
Do routine antibiotics after loop diathermy excision reduce morbidity?
作者信息
Foden-Shroff J, Redman C W, Tucker H, Millinship J, Thomas E, Warwick A, Jones P W
机构信息
Department of Obstetrics and Gynaecology, North Staffordshire Hospital NHS Trust, Harpfields, Stoke on Trent, UK.
出版信息
Br J Obstet Gynaecol. 1998 Sep;105(9):1022-5. doi: 10.1111/j.1471-0528.1998.tb10268.x.
OBJECTIVE
To evaluate whether routinely giving an antibiotic after loop diathermy excision of the cervical transformation zone reduced post-operative vaginal loss.
DESIGN
Prospective, randomised, double-blind placebo controlled parallel study.
PARTICIPANTS
Five hundred women undergoing loop diathermy excision in a colposcopy clinic.
INTERVENTION
Administration of either ofloxacin 400 mg (2x200 mg) once daily for 5 days or an identical placebo.
MAIN OUTCOME MEASURE
Vaginal loss, assessed using a pictorial chart.
RESULTS
No significant difference in post-operative vaginal loss was found.
CONCLUSION
Routine antibiotic prophylaxis after loop diathermy excision is not justified.
目的
评估在宫颈转化区环形电切术后常规给予抗生素是否能减少术后阴道出血量。
设计
前瞻性、随机、双盲、安慰剂对照平行研究。
参与者
500名在阴道镜诊所接受环形电切术的女性。
干预措施
每日一次服用400毫克（2×200毫克）氧氟沙星，共5天，或服用相同的安慰剂。
主要观察指标
使用图片图表评估阴道出血量。
结果
术后阴道出血量无显著差异。
结论
环形电切术后常规预防性使用抗生素并无必要。
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