Massad L S, Halperin C J, Bitterman P
Division of Gynecologic Oncology, Cook County Hospital, Chicago, Illinois 60612, USA.
Gynecol Oncol. 1996 Mar;60(3):400-3. doi: 10.1006/gyno.1996.0062.
Colposcopy is standard for diagnosis of cervical cancer precursors, but the development of diathermy loop electrodes for excision of the cervical transformation zone offers a technique for validation. Loop excision of the transformation zone was performed for 47 consecutive women with dysplasia in colposcopically directed biopsies using 20 x 8-mm electrodes. Specimens were marked for orientation and serially sectioned. All pathology material was reviewed. Although 28% of women had disappearance of dysplasia at the biopsy site, only 9% had no dysplasia in the transformation zone. Half of the women with CIN 1 on directed biopsy had high-grade lesions found in loop excision specimens. Significant discrepancies may be found between the results of colposcopically directed biopsy and loop excision.
阴道镜检查是诊断宫颈癌前病变的标准方法，但用于切除宫颈转化区的透热环形电极的发展提供了一种验证技术。使用20×8毫米电极，对47例在阴道镜引导活检中发现发育异常的连续女性进行了转化区环形切除术。标本进行了定向标记并连续切片。所有病理材料均经过复查。尽管28%的女性活检部位发育异常消失，但只有9%的女性转化区无发育异常。在引导活检中诊断为CIN 1的女性中，有一半在环形切除标本中发现了高级别病变。阴道镜引导活检和环形切除的结果之间可能存在显著差异。
