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[窒息性缺氧对脑和心脏影响的特异性评估。在具有保护活性物质研究中的应用]

[Specific assessment of the cerebral and cardiac effects of asphyxic hypoxia. Application to the study of substances with protective activity].

作者信息

Plotkine M, Lionsquy C, Caillard C, Boulu R, Rossignol P

出版信息

Eur J Toxicol Environ Hyg. 1976 Jul-Aug;9(4):241-4.

PMID:976333
Abstract

The influence of asphyxia on electrocorticogram (E. Co. G.) and electrocardiogram (E. C. G.) has been studied in curarized rats. The delay between the heightening of the ST component of E. C. G. and the disappearance of E. Co. G. pattern was measured. It provided more useful information on cerebral survival during asphyxia than the only study of E. Co. G. did. This delay was increased (cerebral antihypoxic effect) after intravenous treatment with pyritinol (50 mg/kg), vincamine (5 mg/kg) or propranolol (1 mg/kg), but it was not influenced by pentobarbital (60 mg/kg).

摘要

在箭毒化的大鼠中研究了窒息对脑电图(E.Co.G.)和心电图(E.C.G.)的影响。测量了心电图ST段升高与脑电图波形消失之间的延迟。与仅对脑电图的研究相比,这为窒息期间的脑存活提供了更有用的信息。在用脑复康(50毫克/千克)、长春胺(5毫克/千克)或普萘洛尔(1毫克/千克)静脉治疗后,这种延迟增加(脑抗缺氧作用),但不受戊巴比妥(60毫克/千克)的影响。

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