基因靶向研究开始揭示神经丝蛋白的功能。 - Suppr

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超能文献

Gene targeting studies begin to reveal the function of neurofilament proteins.

作者信息

Hirokawa N, Takeda S

机构信息

Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033 Japan.

出版信息

J Cell Biol. 1998 Oct 5;143(1):1-4. doi: 10.1083/jcb.143.1.1.

DOI:10.1083/jcb.143.1.1

PMID:9763415

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2132816/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12ab/2132816/565b29f0df65/JCB9809030.f1.jpg

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本文引用的文献

Requirement of heavy neurofilament subunit in the development of axons with large calibers.大口径轴突发育中重神经丝亚基的需求。

J Cell Biol. 1998 Oct 5;143(1):195-205. doi: 10.1083/jcb.143.1.195.

Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile.NF-H基因的破坏增加了轴突微管含量和神经丝运输速度：缓解了由毒素β,β'-亚氨基二丙腈引起的轴突病。

J Cell Biol. 1998 Oct 5;143(1):183-93. doi: 10.1083/jcb.143.1.183.

Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation.运动轴突的神经丝依赖性径向生长以及神经丝的轴突组织并不需要神经丝重链亚基（NF-H）或其磷酸化。

J Cell Biol. 1998 Oct 5;143(1):171-81. doi: 10.1083/jcb.143.1.171.

Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content.中型神经丝亚基的缺失会减小轴突直径、降低轻链神经丝（NF-L）水平及神经丝含量。

J Cell Biol. 1998 May 4;141(3):727-39. doi: 10.1083/jcb.141.3.727.

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Exp Neurol. 1997 Nov;148(1):299-316. doi: 10.1006/exnr.1997.6654.

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J Cell Biol. 1996 Nov;135(3):711-24. doi: 10.1083/jcb.135.3.711.

An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments.一种将肌动蛋白微丝连接到中间丝的重要细胞骨架连接蛋白。

Cell. 1996 Aug 23;86(4):655-65. doi: 10.1016/s0092-8674(00)80138-5.

Subunit composition of neurofilaments specifies axonal diameter.神经丝的亚基组成决定轴突直径。

J Cell Biol. 1996 Jun;133(5):1061-9. doi: 10.1083/jcb.133.5.1061.

Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene.神经丝蛋白-L基因无义突变导致鹌鹑神经丝蛋白缺乏。

J Cell Biol. 1993 Apr;121(2):387-95. doi: 10.1083/jcb.121.2.387.

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis.表达人神经丝重链基因的转基因小鼠中的进行性神经病变：肌萎缩侧索硬化症的小鼠模型

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