Paul R E, Patel A Y, Mirza S, Fisher-Hoch S P, Luby S P
Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
Int J Infect Dis. 1998 Apr-Jun;2(4):197-201. doi: 10.1016/s1201-9712(98)90052-2.
Antibodies to dengue viruses have occasionally been reported in individuals in Pakistan, but the frequency of occurrence of dengue infection in Pakistan is unclear. The first confirmed dengue hemorrhagic fever outbreak in Pakistan occurred in 1994. In October 1995, the authors investigated an outbreak of a febrile illness among employees of a construction contractor at a power generation plant in Baluchistan, Pakistan, to determine the cause of illness and recommend appropriate preventive measures.
The work site and living arrangements were inspected, a questionnaire was administered, and serum samples were collected from all consenting contractor employees and their families if they lived at the camp. Sera were analyzed for IgM against dengue virus, using an enzyme-linked immunosorbent assay.
Interviews were conducted with 76 persons (mean age, 42y); 95% were men. Forty-two persons (55%) reported having experienced fever, headache, or myalgia in the preceding 6 weeks. Fifty-seven subjects (75%) had IgM antibodies against at least one dengue serotype; 45 subjects (59%) had IgM antibodies against dengue serotype 2.
This was an outbreak of dengue fever due to multiple serotypes of dengue virus. This confirms that epidemic dengue infection was present in southern Pakistan for 2 consecutive years.
巴基斯坦曾有报告称个别人体内存在登革病毒抗体，但巴基斯坦登革热感染的发生频率尚不清楚。巴基斯坦首次确诊的登革出血热疫情于1994年爆发。1995年10月，作者对巴基斯坦俾路支省一座发电厂的建筑承包商员工中爆发的发热性疾病进行了调查，以确定病因并推荐适当的预防措施。
对工作场所和居住安排进行检查，发放问卷，并从所有同意参与的承包商员工及其居住在营地的家属中采集血清样本。使用酶联免疫吸附测定法分析血清中针对登革病毒的IgM。
对76人（平均年龄42岁）进行了访谈；95%为男性。42人（55%）报告在过去6周内出现过发热、头痛或肌痛。57名受试者（75%）具有针对至少一种登革血清型的IgM抗体；45名受试者（59%）具有针对登革2型血清型的IgM抗体。
这是一次由多种血清型登革病毒引起的登革热疫情。这证实了巴基斯坦南部连续两年存在登革热流行感染。
