Tjebbes G W, van Delft J L, van Haeringen N J
Department of Ophthalmology, University of Leiden, The Netherlands.
J Lipid Mediat. 1993 Oct;8(2):87-93.
The inhibitors of prostaglandin (PG) or leukotriene (LT) synthesis and antagonists of platelet-activating factor (PAF) or LTs are inhibitory in experimental keratitis and clinical symptoms of keratitis are reproduced by application of these lipid mediators. This suggests that PGE2, LTB4, LTD4, and PAF are involved in experimental immunogenic and toxic keratitis. The objective of the present study is the measurement of the concentrations of lipid mediators in the aqueous humour and their release by the cornea and iris during keratitis. In both inflammatory models the concentrations of PGE2, LTB4, LTD4, and PAF in the aqueous humour were significantly increased as compared to their controls. The release of PGE2, LTB4 and LTD4 from the cornea, and of PGE2, LTB4, and PAF from the iris was significantly increased compared to that from control tissues. The results are consistent with a role for these lipid mediators in the inflammatory models. Combined therapeutic use of synthesis inhibitors or antagonists of these mediators in eye inflammation seems possible and may serve as an alternative to topical corticosteroid therapy.
前列腺素（PG）或白三烯（LT）合成抑制剂以及血小板活化因子（PAF）或白三烯拮抗剂在实验性角膜炎中具有抑制作用，并且应用这些脂质介质可重现角膜炎的临床症状。这表明PGE2、LTB4、LTD4和PAF参与了实验性免疫性和中毒性角膜炎。本研究的目的是测量房水中脂质介质的浓度以及角膜炎期间角膜和虹膜释放这些介质的情况。在两种炎症模型中，与对照相比，房水中PGE2、LTB4、LTD4和PAF的浓度均显著升高。与对照组织相比，角膜释放PGE2、LTB4和LTD4以及虹膜释放PGE2、LTB4和PAF均显著增加。这些结果与这些脂质介质在炎症模型中的作用一致。在眼部炎症中联合使用这些介质的合成抑制剂或拮抗剂进行治疗似乎是可行的，并且可能成为局部皮质类固醇治疗的替代方法。
