Kranl C, Zelger B, Kofler H, Heim K, Sepp N, Fritsch P
Department of Dermatology, University of Innsbruck, Austria.
Br J Dermatol. 1998 Jul;139(1):128-31. doi: 10.1046/j.1365-2133.1998.02329.x.
Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall, thought to be derived from persistent Müllerian (synonymous with paramesonephric) epithelium islets in postembryonic life. Spontaneous vaginal adenosis appears to be a fairly common (present in about 10% of adult women) but mostly insignificant coincidental finding. In women prenatally exposed to diethylstilboestrol (DES), vaginal adenosis may arise in up to 90% and is associated with a high risk of vaginal carcinoma. Since the withdrawal of DES from the market, vaginal adenosis has virtually disappeared from the medical literature. A case of vaginal adenosis is presented in a middle-aged woman who had not been prenatally exposed to DES. The lesions differed from the spontaneous type by their sudden appearance, their extent and their pronounced subjective symptoms. It is speculated that protracted oral contraceptive intake may have played a causative role.
阴道腺病的定义是阴道壁内存在化生的宫颈或子宫内膜上皮，被认为源自胚胎后期持续存在的苗勒氏（与副中肾同义）上皮小岛。自发性阴道腺病似乎相当常见（约10%的成年女性存在），但大多是无显著意义的偶然发现。在产前接触己烯雌酚（DES）的女性中，阴道腺病的发生率可能高达90%，且与阴道癌的高风险相关。自从DES退出市场后，阴道腺病实际上已从医学文献中消失。本文报告一例中年女性阴道腺病病例，该女性产前未接触过DES。这些病变与自发性类型不同，表现为突然出现、范围较大且有明显的主观症状。推测长期口服避孕药可能起到了致病作用。
