Sundaram S P, Revathi J, Elango V, Shanthakumari S L
King Institute of Preventive Medicine, Guindy, Madras, India.
Trans R Soc Trop Med Hyg. 1998 Mar-Apr;92(2):164-5. doi: 10.1016/s0035-9203(98)90729-5.
Vibrio cholerae was isolated from 1008 of 3496 stool samples (28.8%) examined in Tamil Nadu State, India, between November 1992 and December 1995. During November and December 1992, 363 of the 370 isolates serotyped (98%) were V. cholerae O139 (Bengal). The epidemic predominantly affected adults (91%; 597/656). Both V. cholerae O1 and O139 serotypes were sometimes isolated in the same locality from different individuals. From January 1993 onwards, the rate of isolation of V. cholerae O139 declined, and in 1995 V. cholerae E1 Tor (serotype O1) was isolated from most of the cases (85.6%; 131/153). V. cholerae E1 Tor has clearly not been replaced by serotype O139, but can survive during inter-epidemic periods and reappear at an opportune moment. The decline of serotype O139 may be due to the development of immunity as a result of repeated exposure.
1992年11月至1995年12月期间，在印度泰米尔纳德邦检测的3496份粪便样本中，有1008份（28.8%）分离出霍乱弧菌。1992年11月和12月期间，在370株进行血清分型的菌株中，有363株（98%）为霍乱弧菌O139（孟加拉型）。该疫情主要影响成年人（91%；597/656）。霍乱弧菌O1和O139血清型有时在同一地区从不同个体中分离出来。从1993年1月起，霍乱弧菌O139的分离率下降，1995年，大多数病例（85.6%；131/153）分离出埃尔托霍乱弧菌（血清型O1）。埃尔托霍乱弧菌显然没有被O139血清型取代，但在两次流行期间可以存活，并在适当的时候再次出现。O139血清型的下降可能是由于反复接触导致免疫力增强。
