Hoge C W, Bodhidatta L, Echeverria P, Deesuwan M, Kitporka P
Department of Bacteriology, Immunology, and Molecular Genetics, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Am J Epidemiol. 1996 Feb 1;143(3):263-8. doi: 10.1093/oxfordjournals.aje.a008737.
Vibrio cholerae O139 Bengal emerged on the Indian subcontinent in late 1992 and was first recognized in Thailand in 1993. To characterize the epidemiology of this disease, a hospital-based case-control study was conducted in Samutsakorn, a port city 30 km southwest of Bangkok. Between November 15, 1993, and June 3, 1994, 366 patients were confirmed to have cholera by culture, including 165 (45%) with O139 Bengal, 191 (52%) with O1 Ogawa, and 10 (3%) with both serogroups. During the same time period the previous year, 319 culture-confirmed cholera cases occurred, all serogroup O1. Questionnaires were obtained from 105 patients with O139 Bengal and 103 with O1 infections; for each case patient, two asymptomatic age- and sex-matched control persons were selected. Of the patients with O139 Bengal infections, 93% were adults (> or = 15 years) compared with 92% of patients with O1 infections. Risk factors for cholera identified by case-control comparisons were similar for the two serogroups and included consumption of untreated water, uncooked seafood, and food served at group gatherings. V. cholerae O139 Bengal has emerged in Thailand as a cause of endemic cholera, with epidemiologic features and incidence similar to those of the preexisting O1 strain.
霍乱弧菌O139孟加拉型于1992年末在印度次大陆出现，并于1993年在泰国首次被识别。为了描述这种疾病的流行病学特征，在曼谷西南30公里处的港口城市沙没沙空进行了一项基于医院的病例对照研究。在1993年11月15日至1994年6月3日期间，366例患者经培养确诊为霍乱，其中165例（45%）为O139孟加拉型，191例（52%）为O1小川型，10例（3%）为两种血清群混合感染。在前一年的同一时期，发生了319例经培养确诊的霍乱病例，均为O1血清群。对105例O139孟加拉型感染患者和103例O1感染患者进行了问卷调查；为每例病例患者挑选了两名年龄和性别匹配的无症状对照者。O139孟加拉型感染患者中93%为成年人（≥15岁），O1感染患者中这一比例为92%。通过病例对照比较确定的霍乱危险因素在两种血清群中相似，包括饮用未经处理的水、食用生海鲜以及在集体聚会中提供的食物。霍乱弧菌O139孟加拉型已在泰国成为地方性霍乱的病因，其流行病学特征和发病率与先前存在的O1菌株相似。
