Hoskin P J, Rembowska A
Mount Vernon Centre for Cancer Treatment, Northwood, UK.
Clin Oncol (R Coll Radiol). 1998;10(4):226-30. doi: 10.1016/s0936-6555(98)80005-8.
The increasing availability of high dose rate (HDR) afterloading units has highlighted the potential use of this form of brachytherapy in an ever wider number of clinical sites. Alongside this, commercial planning systems for brachytherapy offer almost infinite possibilities for the differential loading of applicators in an attempt to produce an ideal dose distribution. Dosimetry in the UK has been based largely on the Manchester and Paris systems; modifications and optimization of the Paris system in HDR brachytherapy have been proposed, but the Manchester dosimetry system, with its emphasis on dose homogeneity throughout the specified treatment plane or specified treatment volume, can also be successfully applied, unmodified, in HDR dosimetry. A comparison of Manchester, Paris and optimized distributions for an HDR implant is presented, illustrating how subjectively and on the basis of dose-volume histograms, optimization has in this clinical case failed to improve on the uniformity of the Manchester rules distribution. It is proposed that optimization systems should have an option to apply these rules with further individualized clinical optimization if required. This would permit uniform reporting of implant parameters where, by describing the clinical target volume, the total reference air kerma and initial distribution of dwell times will be defined.
高剂量率(HDR)后装治疗设备的日益普及,凸显了这种近距离放射治疗形式在越来越多临床场所的潜在应用。与此同时,近距离放射治疗的商业计划系统为施源器的差异加载提供了几乎无限的可能性,以期产生理想的剂量分布。英国的剂量测定主要基于曼彻斯特系统和巴黎系统;有人提出了在HDR近距离放射治疗中对巴黎系统进行修改和优化,但曼彻斯特剂量测定系统强调在指定治疗平面或指定治疗体积内的剂量均匀性,也可直接成功应用于HDR剂量测定。本文对HDR植入的曼彻斯特、巴黎和优化分布进行了比较,说明了在该临床病例中,基于剂量体积直方图,主观上优化如何未能改善曼彻斯特规则分布的均匀性。建议优化系统应具备根据需要进一步进行个体化临床优化时应用这些规则的选项。这将允许在描述临床靶体积、总参考空气比释动能和驻留时间的初始分布时,对植入参数进行统一报告。