Liu P Y, Hu B S, Fung C P, Lau Y J, Shi Z Y, Lin Y H
Section of Infectious Diseases (PY-FL), Shalu Tungs' Memorial Hospital, Taiwan, Republic of China.
Diagn Microbiol Infect Dis. 1998 Aug;31(4):511-5. doi: 10.1016/s0732-8893(98)00047-9.
Previous studies have suggested that penicillin-resistant pneumococcal isolates (especially those with MIC > 1 microgram/mL) usually are clonally related. To test this hypothesis, the molecular epidemiology of 29 clinical isolates of penicillin-resistant pneumococci (of which 83% were also resistant to either cefotaxime or ceftriaxone) collected in central Taiwan was investigated by pulsed field gel electrophoresis. Twenty-seven distinct patterns were identified. Our results indicate that an increase in penicillin-resistant S. pneumoniae between April 1993 and June 1994 in central Taiwan is not due to the clonal dissemination of a limited number of epidemic strains.
以往的研究表明，对青霉素耐药的肺炎球菌分离株（尤其是那些最低抑菌浓度>1微克/毫升的菌株）通常具有克隆相关性。为了验证这一假说，我们通过脉冲场凝胶电泳对在台湾中部收集的29株对青霉素耐药的肺炎球菌临床分离株（其中83%也对头孢噻肟或头孢曲松耐药）的分子流行病学进行了研究。共鉴定出27种不同的模式。我们的结果表明，1993年4月至1994年6月间台湾中部对青霉素耐药的肺炎链球菌数量增加并非由于少数流行菌株的克隆传播。
