Pathak C L
Experientia. 1976 Oct 15;32(10):1295-7. doi: 10.1007/BF01953102.
It was observed that the heart rate was minimum at zero transmural pressure. The mean heart rate at zero transmural pressure was 23+/-5/min. This mean heart rate increased from 23+/-5/min to a peak value of 40+/-6/min (74% acceleration) when the transmural pressure was raised from 0 to +4 mm Hg and to a similar peak value of 36+/-8/min (56% acceleration) when the transmural pressure was lowered from 0 to -4 mm Hg. The peak values attained at +/-4 mm Hg were highly significant (p less than 0.001). It is concluded that the heart rate at zero transmural pressure represents the basic intrinsic pacemaker frequency independent of neural, humoral, thermal and haemodynamically induced mechanical influences.
据观察，跨壁压力为零时心率最低。跨壁压力为零时的平均心率为23±5次/分钟。当跨壁压力从0升高至+4 mmHg时，该平均心率从23±5次/分钟增加到峰值40±6次/分钟（加速74%）；当跨壁压力从0降低至-4 mmHg时，平均心率增加到类似的峰值36±8次/分钟（加速56%）。在±4 mmHg时达到的峰值具有高度显著性（p<0.001）。结论是，跨壁压力为零时的心率代表了独立于神经、体液、热和血流动力学诱导的机械影响的基本固有起搏频率。
