p53在不同亚型肠化生及胃癌中的过表达。
Overexpression of p53 in different subtypes of intestinal metaplasia and gastric cancer.
作者信息
Wu M S, Shun C T, Lee W C, Chen C J, Wang H P, Lee W J, Sheu J C, Lin J T
机构信息
Department of Internal Medicine, National Taiwan University Hospital, Taipei.
出版信息
Br J Cancer. 1998 Oct;78(7):971-3. doi: 10.1038/bjc.1998.611.
Abstract
p53 immunostaining was evaluated in cancerous epithelia and adjacent intestinal metaplasia of 135 gastric cancer specimens. The differential p53 overexpression in different subtypes of intestinal metaplasia and gastric cancer suggests that type III intestinal metaplasia is the commonest lesion in dysplasia-carcinoma transition, particularly in the intestinal type of gastric cancer.
摘要
在135例胃癌标本的癌上皮及相邻肠化生组织中评估p53免疫染色情况。不同亚型肠化生和胃癌中p53表达差异提示，III型肠化生是发育异常-癌转变中最常见的病变，尤其是在肠型胃癌中。
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