Rader J S, Neuman R J, Brady J, Babb S, Temple S, Kost E, Mutch D G, Herzog T J
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Obstet Gynecol. 1998 Oct;92(4 Pt 1):589-95. doi: 10.1016/s0029-7844(98)00275-0.
The familial clustering of ovarian, breast, endometrial, colon; and prostate cancer was compared in first-degree relatives of probands with invasive and borderline ovarian cancer to determine coaggregation.
Probands (n=392), who had been patients in the Division of Gynecologic Oncology at Washington University, were ascertained consecutively. Family history on 2192 first-degree relatives was collected by personal interviews of the probands and other family members. Estimates of prevalence of cancers in first-degree relatives of the two proband groups were compared. Survival analysis was used to examine the age-at-onset distribution of each cancer in relatives of invasive probands versus relatives of borderline probands.
Among the relatives were 24 cases of ovarian cancer, 46 cases of breast cancer, 13 cases of endometrial cancer, and 25 and 28 cases of colon and prostate cancer, respectively. There were no significant differences in the prevalence of any of these cancers in relatives of the invasive and borderline probands. Cumulative lifetime risk estimates did not differ between the relatives of the two groups for any cancers. Age-at-onset of ovarian cancer did not differ between probands with positive family histories of the five cancers and those with negative histories. The inability to reject the null hypothesis of no differences in the first-degree relatives of our two study groups might be from insufficient power to detect small differences, given our sample size.
These results suggest that relatives of patients with invasive and borderline ovarian cancer might share similar cancer risks and age-at-onset distributions.
比较侵袭性和交界性卵巢癌先证者的一级亲属中卵巢癌、乳腺癌、子宫内膜癌、结肠癌和前列腺癌的家族聚集情况，以确定共聚集性。
连续确定曾在华盛顿大学妇科肿瘤学部门就诊的先证者（n = 392）。通过对先证者和其他家庭成员进行个人访谈，收集了2192名一级亲属的家族史。比较了两组先证者一级亲属中癌症的患病率估计值。采用生存分析来检查侵袭性先证者亲属与交界性先证者亲属中每种癌症的发病年龄分布。
亲属中分别有24例卵巢癌、46例乳腺癌、13例子宫内膜癌以及25例和28例结肠癌和前列腺癌。侵袭性和交界性先证者的亲属中，这些癌症的患病率均无显著差异。两组亲属中任何癌症的累积终生风险估计值均无差异。有这五种癌症家族史阳性的先证者与家族史阴性的先证者，其卵巢癌发病年龄无差异。鉴于我们的样本量，无法拒绝两个研究组一级亲属无差异的零假设可能是由于检测微小差异的能力不足。
这些结果表明，侵袭性和交界性卵巢癌患者的亲属可能具有相似的癌症风险和发病年龄分布。
