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Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus.增加人类患乳腺癌易感性的等位基因可能与谷丙转氨酶基因座有关。
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Evaluating genetic association among ovarian, breast, and endometrial cancer: evidence for a breast/ovarian cancer relationship.评估卵巢癌、乳腺癌和子宫内膜癌之间的遗传关联性：乳腺癌与卵巢癌关系的证据。
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Body mass index and risk of breast cancer. A prospective study of 23,826 Norwegian women.体重指数与乳腺癌风险。对23826名挪威女性的前瞻性研究。
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Familial breast-ovarian cancer locus on chromosome 17q12-q23.位于17号染色体q12 - q23区域的家族性乳腺 - 卵巢癌基因座。
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Epidemiology of breast cancer in families in Iceland.冰岛家庭中乳腺癌的流行病学
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Familial association of breast/ovarian carcinoma.乳腺癌/卵巢癌的家族关联。
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乳腺癌女性亲属患前列腺癌、卵巢癌和子宫内膜癌的风险。

Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer.

作者信息

Tulinius H, Egilsson V, Olafsdóttir G H, Sigvaldason H

机构信息

Icelandic Cancer Registry, Reykjavik.

出版信息

BMJ. 1992 Oct 10;305(6858):855-7. doi: 10.1136/bmj.305.6858.855.

DOI:10.1136/bmj.305.6858.855
PMID:1422397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1883041/
Abstract

OBJECTIVE

To investigate the risk of prostate, ovarian, and endometrial cancer among relatives of patients with breast cancer.

DESIGN

Cohort study of 947 pedigrees in which the proband had breast cancer, linked with the Icelandic cancer registry.

SETTING

Iceland.

SUBJECTS

The 947 pedigrees included 29,725 people, of whom 1539 had breast cancer, 467 had prostate cancer, 135 ovarian cancer, and 105 endometrial cancer.

MAIN OUTCOME MEASURES

Risk of prostate, ovarian, and endometrial cancer among blood relatives of women with breast cancer compared with risk in spouses.

RESULTS

The risk of prostate cancer was significantly raised for all relatives (1.5), first degree relatives (1.4), and second degree relatives (1.3) of women with breast cancer. Risk of ovarian cancer was raised for all relatives (1.9) and first degree relatives (1.9) and risk of endometrial cancer was raised for all relatives only (1.9). The risk of prostate cancer was raised if the proband with breast cancer had a first degree relative with prostate cancer.

CONCLUSIONS

Coaggregation exists between breast cancer and cancers of the prostate, ovaries, and endometrium. This risk relation is probably based on genes which act by increasing the risk for cancer at these sites. Environmental factors that are common among relatives may also play a part. Continued research is required into pathophysiological mechanisms that could explain these observations.

摘要

目的

调查乳腺癌患者亲属患前列腺癌、卵巢癌和子宫内膜癌的风险。

设计

对947个先证者患有乳腺癌的家系进行队列研究，并与冰岛癌症登记处建立联系。

地点

冰岛。

研究对象

947个家系包括29725人，其中1539人患有乳腺癌，467人患有前列腺癌，135人患有卵巢癌，105人患有子宫内膜癌。

主要观察指标

乳腺癌女性血亲患前列腺癌、卵巢癌和子宫内膜癌的风险与配偶的风险相比较。

结果

乳腺癌女性的所有亲属（风险比为1.5）、一级亲属（风险比为1.4）和二级亲属（风险比为1.3）患前列腺癌的风险均显著升高。所有亲属（风险比为1.9）和一级亲属（风险比为1.9）患卵巢癌的风险升高，仅所有亲属患子宫内膜癌的风险升高（风险比为1.9）。如果患有乳腺癌的先证者有患前列腺癌的一级亲属，则患前列腺癌的风险会升高。

结论

乳腺癌与前列腺癌、卵巢癌和子宫内膜癌之间存在共同聚集现象。这种风险关系可能基于通过增加这些部位患癌风险而起作用的基因。亲属中常见的环境因素也可能起作用。需要对能够解释这些观察结果的病理生理机制进行持续研究。