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颈动脉内膜切除术和腹主动脉瘤修复术:对于80岁以上的患者来说,这些是合理的治疗方法吗?

Carotid endarterectomy and abdominal aoritc aneurysm repair: are these reasonable treatments for patients over age 80?

作者信息

Wong D T, Ballard J L, Killeen J D

机构信息

Department of General Surgery, Loma Linda University Medical Center, California 92354, USA.

出版信息

Am Surg. 1998 Oct;64(10):998-1001.

PMID:9764711
Abstract

Due to the aging of America, increased numbers of very elderly patients require peripheral vascular surgery. From April 1980 to November 1997, 191 patients age 80 years or older had carotid endarterectomy (CEA) and/or abdominal aortic aneurysm (AAA) repair at Loma Linda University Medical Center. The total perioperative stroke and death rate in the CEA group was 2.9 per cent. Mean postoperative cumulative survival in this group was 8.4 years. The cumulative stroke-free survival rate was 95.5 per cent for all yearly postoperative intervals up to 12 years. The perioperative mortality rate was 10.7 per cent in the nonruptured AAA group and 53.8 per cent in the ruptured AAA group (P < 0.00001). Mean cumulative survival was 8.6 years in the nonruptured AAA group and 1.1 years in the ruptured AAA group (P = 0.0001). These data support the conclusion that CEA and nonemergent AAA repair in octo- and nonagenarians are safe and effective in prolonging stroke-free and rupture-free survival. The utility of ruptured AAA repair in this age-group is less clear.

摘要

由于美国人口老龄化,需要进行外周血管手术的高龄患者数量不断增加。1980年4月至1997年11月,191名80岁及以上的患者在洛马林达大学医学中心接受了颈动脉内膜切除术(CEA)和/或腹主动脉瘤(AAA)修复术。CEA组围手术期总的中风和死亡率为2.9%。该组术后平均累积生存率为8.4年。在长达12年的所有术后年度间隔中,无中风累积生存率为95.5%。未破裂AAA组的围手术期死亡率为10.7%,破裂AAA组为53.8%(P<0.00001)。未破裂AAA组的平均累积生存率为8.6年,破裂AAA组为1.1年(P = 0.0001)。这些数据支持以下结论:在八旬和九旬老人中进行CEA和非急诊AAA修复术在延长无中风和无破裂生存期方面是安全有效的。在这个年龄组中,破裂AAA修复术的效用尚不太明确。

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