对初始CD8(+)淋巴细胞的共刺激可诱导CD4表达并允许1型人类免疫缺陷病毒感染。
Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.
作者信息
Kitchen S G, Korin Y D, Roth M D, Landay A, Zack J A
机构信息
Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA.
出版信息
J Virol. 1998 Nov;72(11):9054-60. doi: 10.1128/JVI.72.11.9054-9060.1998.
Abstract
Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells responded with greater expression of CD4 than did CD45RO+ cells. CD8(+) lymphocytes derived from fetal or newborn sources exhibited a greater tendency to express CD4, consistent with their naive states. This mechanism of infection suggests HIV-induced perturbation of the CD8 arm of the immune response and could explain the generally rapid disease progression seen in HIV-infected children.
摘要
1型人类免疫缺陷病毒（HIV-1）感染需要CD4在细胞表面表达。抗CD3和抗CD28抗体或同种异体树突状细胞对CD8(+)/CD4(-) T淋巴细胞的共刺激诱导了CD4的表达，并使这些CD8细胞易受HIV-1感染。初始CD45RA+细胞比CD45RO+细胞对CD4的表达反应更强。来自胎儿或新生儿来源的CD8(+)淋巴细胞表现出更大的CD4表达倾向，这与其初始状态一致。这种感染机制表明HIV诱导了免疫反应中CD8臂的扰动，并且可以解释在HIV感染儿童中普遍观察到的疾病快速进展情况。
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