MexAB-OprM多药外排系统对铜绿假单胞菌群体感应的影响。
Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa.
作者信息
Evans K, Passador L, Srikumar R, Tsang E, Nezezon J, Poole K
机构信息
Department of Microbiology and Immunology, Queen's University, Kingston, Ontario K7L 3N6, Canada.
出版信息
J Bacteriol. 1998 Oct;180(20):5443-7. doi: 10.1128/JB.180.20.5443-5447.1998.
Abstract
Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-1, consistent with an observed reduction in lasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-1-dependent activation of lasI and the virulence genes.
摘要
高表达MexAB-OprM多药外排系统的铜绿假单胞菌nalB突变体产生的几种已知受群体感应调节的细胞外毒力因子水平降低。此类突变体还产生较少的酰化高丝氨酸内酯自诱导物PAI-1，这与观察到的lasI表达降低一致。这些数据表明PAI-1是MexAB-OprM的底物，其从高表达MexAB-OprM的细胞中排出限制了lasI和毒力基因的PAI-1依赖性激活。
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