Kojima M, Nagasawa S, Lee Y E, Takeichi Y, Tsuda E, Mabuchi N
Department of Neurosurgery, St. Joseph Hospital for Crippled Children, Kyoto, Japan.
Neurosurgery. 1998 Oct;43(4):776-81. doi: 10.1097/00006123-199810000-00026.
We evaluated the prevalence and features of cerebral aneurysms in the family members of people with asymptomatic aneurysms among 8680 participants undergoing magnetic resonance angiography.
Of the 8680 participants, 380 had family histories of aneurysms and 8300 did not. The prevalence and features of asymptomatic aneurysms were compared in these two subgroups. In addition, the prevalence in all living first- or second-degree relatives was evaluated in 20 families.
The prevalence of asymptomatic aneurysms was 7.0% (606 of 8680 participants) overall and 10.5% (40 of 380 participants) and 6.8% (566 of 8300 participants) in the subgroups with and without family histories of aneurysms, respectively. The prevalence in the female participants with family histories of aneurysms (12.3%, 28 of 228 participants) was higher than that in the male participants with family histories of aneurysms (7.9%, 12 of 152 participants) (P < 0.0001). Compared with the entire group, this subgroup more commonly showed aneurysms situated at the junction of the internal carotid and posterior communicating arteries (P < 0.0005) and at the middle cerebral artery (P < 0.0001). The prevalence of aneurysms in 115 members of the 20 families was 33.9%. Although the members of 14 families with aneurysmal subarachnoid hemorrhage showed higher prevalence of ruptured and asymptomatic aneurysms (42.1%) than did the members of 6 families with only asymptomatic aneurysms (17.9%), the former had very low prevalence of asymptomatic aneurysms.
The prevalence of aneurysms is significantly elevated in family members of people with asymptomatic aneurysms. It is suggested that familial asymptomatic aneurysms are more likely to rupture in families having members with aneurysmal subarachnoid hemorrhage than in those without.
在8680名接受磁共振血管造影的参与者中，我们评估了无症状动脉瘤患者家庭成员中脑动脉瘤的患病率及特征。
8680名参与者中，380人有动脉瘤家族史，8300人没有。比较这两个亚组中无症状动脉瘤的患病率及特征。此外，对20个家庭中所有在世的一级或二级亲属的患病率进行了评估。
无症状动脉瘤的总体患病率为7.0%（8680名参与者中的606人），有动脉瘤家族史的亚组患病率为10.5%（380名参与者中的40人），无动脉瘤家族史的亚组患病率为6.8%（8300名参与者中的566人）。有动脉瘤家族史的女性参与者患病率（12.3%，228名参与者中的28人）高于有动脉瘤家族史的男性参与者患病率（7.9%，152名参与者中的12人）（P<0.0001）。与整个组相比，该亚组更常见于颈内动脉与后交通动脉交界处（P<0.0005）和大脑中动脉处（P<0.0001）的动脉瘤。20个家庭的115名成员中动脉瘤患病率为33.9%。尽管14个有动脉瘤性蛛网膜下腔出血家庭的成员中破裂和无症状动脉瘤的患病率（42.1%）高于6个仅有无症状动脉瘤家庭的成员（17.9%），但前者无症状动脉瘤的患病率非常低。
无症状动脉瘤患者家庭成员中动脉瘤的患病率显著升高。提示有动脉瘤性蛛网膜下腔出血患者的家庭中，家族性无症状动脉瘤比无此类患者的家庭更易破裂。
