一种新型抗肿瘤抗生素，和佐霉素。

A new antitumor antibiotic, kazusamycin.

作者信息

Umezawa I, Komiyama K, Oka H, Okada K, Tomisaka S, Miyano T, Takano S

出版信息

J Antibiot (Tokyo). 1984 Jul;37(7):706-11. doi: 10.7164/antibiotics.37.706.

DOI:10.7164/antibiotics.37.706

Abstract

A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin suggest that the molecular formula of this antibiotic is C33H48O7 (MW 556).

摘要

一种新的抗生素和佐霉素，是从链霉菌属81 - 484号菌株的培养液中分离出来的，它对实验性小鼠肿瘤显示出抗肿瘤活性。这种抗生素对革兰氏阳性菌和革兰氏阴性菌均无抗菌活性，但在体外对HeLa细胞表现出很强的细胞毒活性。和佐霉素的化学及物理化学性质表明，这种抗生素的分子式为C33H48O7（分子量556）。