与青少年粒单核细胞白血病相关的7号染色体单体的细胞遗传学克隆性分析：B细胞和自然杀伤细胞存在克隆性，但T细胞不存在。
Cytogenetic clonality analysis in monosomy 7 associated with juvenile myelomonocytic leukemia: clonality in B and NK cells, but not in T cells.
作者信息
Nakazawa T, Koike K, Agematsu K, Itoh S, Hagimoto R, Kitazawa Y, Higuchi T, Sawai N, Matsui H, Komiyama A
机构信息
Department of Pediatrics, Shinshu University School of Medicine, Asahi, Matsumoto, Japan.
出版信息
Leuk Res. 1998 Oct;22(10):887-92. doi: 10.1016/s0145-2126(98)00090-3.
It remains unclear which lymphoid lineages are involved in juvenile myelomonocytic leukemia (JMML). We report a JMML patient who acquired monosomy 7 after intensive chemotherapy. In this case, the expression of monosomy 7 was analyzed in T, B and natural killer (NK) cells highly purified from peripheral blood mononuclear cells of the patient. The fluorescence in situ hybridization method revealed the expression of monosomy 7 in B cells, but not T cells. Half of the NK cells expressed monosomy 7; when NK cells were divided into CD2- and CD2+ populations, this abnormality was positive in 91.1% of CD2- NK cells but in only 14.7% of CD2+ NK cells. These results suggest that, in this JMML patient who acquired monosomy 7 after intensive chemotherapy, B cells and half of NK cells, but not T cells, have monosomy 7.
目前尚不清楚哪些淋巴谱系参与了青少年粒单核细胞白血病（JMML）。我们报告了一名在强化化疗后出现7号染色体单体的JMML患者。在该病例中，对从患者外周血单个核细胞高度纯化的T细胞、B细胞和自然杀伤（NK）细胞中的7号染色体单体表达进行了分析。荧光原位杂交方法显示B细胞中有7号染色体单体表达，但T细胞中没有。一半的NK细胞表达7号染色体单体；当NK细胞分为CD2-和CD2+群体时，这种异常在91.1%的CD2-NK细胞中呈阳性，但在仅14.7%的CD2+NK细胞中呈阳性。这些结果表明，在这名强化化疗后出现7号染色体单体的JMML患者中，B细胞和一半的NK细胞有7号染色体单体，而T细胞没有。
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