Massaad L, Prieur M, Leonard C, Dutrillaux B
Biology Section, Institut Curie, Bicêtre, France.
Cancer Genet Cytogenet. 1990 Jan;44(1):131-7. doi: 10.1016/0165-4608(90)90205-o.
A monosomy 7 was first detected in a 6-month-old boy with a chronic myelomonocytic leukemia. After etoposide treatment, relapse occurred after 29 months, with transformation of the disease into an acute myeloblastic leukemia. After bone marrow transplantations, two abnormal clones were found in marrow cells: 45,XY,-7,del(12)(p11p12)(66%), and 45,XY,-7,t(3;12)(q26;p12)(33%). Several karyotypic studies performed until the terminal phase exhibited the persistence of these two clones in the same proportion, although both independently acquired additional and often similar anomalies. The clone with t(3;12) acquired der(7),der(11),der(17),der(8),der(10),-5,-20, and the clone with del(12p), del(5q),der(4),der(8),der(10),der(17),-5,-20. The anomalies in 12p12 appear to represent an important although secondary event of the neoplastic process. The other anomalies may correspond to either those of a secondary acute nonlymphocytic leukemia, since they occurred after treatment by etoposide and alkylating agents, or to the natural evolution of myelomonocytic leukemia.
在一名患有慢性粒单核细胞白血病的6个月大男孩中首次检测到单体7。依托泊苷治疗后，29个月后复发，疾病转变为急性髓细胞性白血病。骨髓移植后，在骨髓细胞中发现了两个异常克隆：45,XY,-7,del(12)(p11p12)(66%)和45,XY,-7,t(3;12)(q26;p12)(33%)。直到末期进行的几项核型研究显示这两个克隆以相同比例持续存在，尽管两者都独立获得了额外的且通常相似的异常。带有t(3;12)的克隆获得了der(7)、der(11)、der(17)、der(8)、der(10)、-5、-20，而带有del(12p)的克隆获得了del(5q)、der(4)、der(8)、der(10)、der(17)、-5、-20。12p12的异常似乎代表了肿瘤形成过程中一个重要的继发性事件。其他异常可能要么对应于继发性急性非淋巴细胞白血病的异常，因为它们发生在依托泊苷和烷化剂治疗之后，要么对应于粒单核细胞白血病的自然演变。
