Shelley E D, Shelley W B, Talanin N Y
Division of Dermatology, Department of Medicine, Medical College of Ohio, PO Box 10008, Toledo, OH 43699-0008, USA.
Br J Dermatol. 1998 Aug;139(2):319-24. doi: 10.1046/j.1365-2133.1998.02376.x.
Staphylococcal scalded skin syndrome (SSSS), not previously recorded as a chronic disease, persisted for 2 years in a 50-year-old woman with epilepsy and cerebellar ataxia. Lesions initially suggestive of erythema multiforme and toxic epidermal necrolysis evolved over 2 years into those typical for SSSS, with extensive erosions and subcorneal blisters, showing an epidermal split at the granular cell layer. Exfoliatin A-producing phage I-III Staphylococcus aureus, previously linked only to acute mild adult cases of SSSS, was cultured from purulent discharge in the patient's eyes, ears and open skin lesions. The roles of epilepsy and antiepileptic medications are discussed as possible predisposing factors.
葡萄球菌性烫伤样皮肤综合征（SSSS），此前未被记录为一种慢性疾病，在一名患有癫痫和小脑共济失调的50岁女性中持续了2年。最初提示多形红斑和中毒性表皮坏死松解症的皮损在2年时间里逐渐演变成SSSS的典型皮损，出现广泛糜烂和角质层下水疱，在颗粒细胞层显示表皮分裂。产剥脱毒素A的噬菌体I-III型金黄色葡萄球菌，此前仅与SSSS的急性轻症成人病例有关，从该患者眼睛、耳朵及开放性皮肤损害处的脓性分泌物中培养出。文中讨论了癫痫和抗癫痫药物作为可能的易感因素所起的作用。
