Ródenas J M, Herranz M T, Tercedor J
Department of Dermatology, Hospital General Universitario Morales Meseguer, Av. Marqués de los Vélez, 30008 Murcia, Spain.
Br J Dermatol. 1998 Sep;139(3):508-11. doi: 10.1046/j.1365-2133.1998.02420.x.
Autoimmune progesterone dermatitis is a rare manifestation of hypersensitivity to endogenous hormones with polymorphic clinical manifestations. We report a 28-year-old woman with a 5-year history of mucocutaneous erythema multiforme occurring cyclically in the premenstrual period. Progesterone sensitivity was demonstrated by challenge test with medroxyprogesterone acetate. Treatments with oestrogens, tamoxifen and triptorelin had to be withdrawn because of intolerable adverse effects. Oophorectomy finally cured the disease.
自身免疫性孕酮性皮炎是一种对内源性激素过敏的罕见表现，具有多种临床表现。我们报告一名28岁女性，有5年多形性红斑黏膜皮肤型病史，在月经前期周期性发作。通过醋酸甲羟孕酮激发试验证实了孕酮敏感性。由于无法耐受的不良反应，不得不停用雌激素、他莫昔芬和曲普瑞林治疗。卵巢切除术最终治愈了该疾病。
