Galimberti R, Kowalczuk A, Hidalgo Parra I, Gonzalez Ramos M, Flores V
Department of Dermatology, Hospital Italiano, Gascón 450, CP 1181, Buenos Aires, Argentina.
Br J Dermatol. 1998 Sep;139(3):522-6. doi: 10.1046/j.1365-2133.1998.02424.x.
Skin invasion by Aspergillus is infrequent. We here describe six immunocompromised patients with skin manifestations caused by Aspergillus. A heart transplant recipient developed a primary cutaneous aspergillosis; two patients (one with chronic granulomatous disease and another treated with a high dose of corticosteroids) presented with nodular lesions secondary to haematogenous dissemination; and three patients with acute myelogenous leukaemia had skin dissemination by contiguity from orbit and sinus invasion. A. flavus was isolated in the three cases of leukaemia; the infection was due to A. fumigatus in the transplant recipient; A. fumigatus and A. versicolor were isolated in the patients with the secondary aspergillosis. In most cases, amphotericin B was useful, with clinical and mycological remission in four patients. A patient with leukaemia died without undergoing treatment, and a child carrier of chronic granulomatous disease died after only 12 days of treatment.
曲霉菌侵袭皮肤的情况并不常见。我们在此描述6例因曲霉菌引起皮肤表现的免疫功能低下患者。一名心脏移植受者发生了原发性皮肤曲霉菌病；两名患者（一名患有慢性肉芽肿病，另一名接受高剂量皮质类固醇治疗）出现血行播散继发的结节性病变；三名急性髓性白血病患者因眼眶和鼻窦侵袭相邻部位而出现皮肤播散。在三例白血病患者中分离出黄曲霉菌；移植受者的感染是由烟曲霉菌引起的；在继发性曲霉菌病患者中分离出烟曲霉菌和杂色曲霉菌。在大多数情况下，两性霉素B是有效的，4例患者实现了临床和真菌学缓解。一名白血病患者未接受治疗死亡，一名慢性肉芽肿病患儿在治疗仅12天后死亡。
