Spencer R P, Lang B J
Growth. 1976 Sep;40(3):211-6.
An approach to quantification of blood flow in growing malignant tumors, by relating the specific rate of change of flow to the specific rate of change of tumor weight or volume, was discussed. This model, previously noted to hold for many animal tumors, offers a good description of blood flow in the KHT sarcoma in C3H mice. The same tumor responds to radiation therapy, and simple expressions were given of the relationship of flow per unit volume, at 2 points in time, to the original radiation dose. Since most animal tumors show a nonviable or necrotic volume, a description of the phenomenon was given for the C3H/Bi mammary carcinoma by noting that the percent of nonviable tissue approaches a limiting (asymptomic)value.
讨论了一种通过将血流的特定变化率与肿瘤重量或体积的特定变化率相关联来量化生长中的恶性肿瘤血流的方法。该模型先前被指出适用于许多动物肿瘤，它很好地描述了C3H小鼠KHT肉瘤中的血流情况。同一肿瘤对放射治疗有反应，并给出了两个时间点单位体积血流与原始放射剂量之间关系的简单表达式。由于大多数动物肿瘤都有一个无活力或坏死的体积，通过指出无活力组织的百分比接近一个极限（渐近）值，对C3H/Bi乳腺癌的这一现象进行了描述。
