青少年型糖尿病患者的胰腺外分泌功能
Exocrine pancreatic function in juvenile-onset diabetes mellitus.
作者信息
Frier B M, Saunders J H, Wormsley K G, Bouchier I A
出版信息
Gut. 1976 Sep;17(9):685-91. doi: 10.1136/gut.17.9.685.
Abstract
Exocrine pancreatic function was studied in 20 juvenile-onset diabetics, seven maturity-onset diabetics, and five patients with diabetes secondary to chronic pancreatitis. The results were compared with 13 non-diabetic controls. The outputs of bicarbonate, trypsin, and amylase were reduced in the diabetic patients in response to intravenous secretin and CCK-PZ. In the juvenile-onset group, exocrine pancreatic secretory capacity was reduced in 80% of the patients, and the severity of the reduction was related to the duration of the diabetes. The reduction in pancreatic secretory capacity must be taken into consideration when interpreting pancreatic exocrine function in patients with diabetes.
摘要
对20例青少年发病型糖尿病患者、7例成年发病型糖尿病患者以及5例继发于慢性胰腺炎的糖尿病患者的外分泌胰腺功能进行了研究。将结果与13名非糖尿病对照者进行了比较。糖尿病患者静脉注射促胰液素和胆囊收缩素-胰酶泌素后，碳酸氢盐、胰蛋白酶和淀粉酶的分泌量减少。在青少年发病型组中，80%的患者外分泌胰腺分泌能力降低，且降低的严重程度与糖尿病病程相关。在解释糖尿病患者的胰腺外分泌功能时，必须考虑胰腺分泌能力的降低。
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