一种致动脉粥样硬化的中带脂蛋白：糖尿病合并高脂血症患者冠状动脉疾病的危险因素。

An atherogenic midband lipoprotein: a risk factor for coronary artery disease in diabetes mellitus with hyperlipidemia.

作者信息

Kawano M, Shinomiya M, Kanzaki T, Morisaki N, Shirai K, Saito Y, Yoshida S

机构信息

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

出版信息

Diabetes Res Clin Pract. 1998 Jul;41(1):45-8. doi: 10.1016/s0168-8227(98)00057-6.

DOI:10.1016/s0168-8227(98)00057-6

PMID:9768371

Abstract

On polyacrylamide gel (PAG) disc electrophoresis of serum lipoproteins, the band(s) which migrates between pre beta- and beta-lipoproteins was more frequently observed in hyperlipidemics with diabetes mellitus (73%), than in those without diabetes mellitus (37%) (P < 0.01). Those bands were seen at three positions between pre beta- and beta-lipoproteins. A higher incidence of coronary artery disease (CAD) was observed in patients with midband as a shoulder of beta-lipoproteins (44%), than in those without midband (11%) (P < 0.05) after the matching of other risk factors. These results suggest that midband as a shoulder of beta-lipoproteins may be a risk factor for CAD in diabetes mellitus with hyperlipidemia.

摘要

在血清脂蛋白的聚丙烯酰胺凝胶（PAG）圆盘电泳中，在β-前脂蛋白和β-脂蛋白之间迁移的条带在糖尿病高脂血症患者中（73%）比在无糖尿病患者中（37%）更常出现（P<0.01）。这些条带出现在β-前脂蛋白和β-脂蛋白之间的三个位置。在其他危险因素匹配后，β-脂蛋白肩部出现中带的患者中冠状动脉疾病（CAD）的发生率（44%）高于无中带的患者（11%）（P<0.05）。这些结果表明，β-脂蛋白肩部的中带可能是糖尿病高脂血症患者CAD的一个危险因素。