Handa Y
Jpn Heart J. 1978 Mar;19(2):236-51. doi: 10.1536/ihj.19.236.
Grossly abnormal serum lipoprotein (Lp) profile which appeared as a broad-midband pattern (BMP) in PAG electrophoresis was detected in 67% of uremic patients maintained by prolonged hemodialysis therapy (hemodialysis patients). It was revealed that BMP was ascribed to the presence of a discrete series of Lps which were intermediate between beta-migrating LDL and pre-beta-migrating VLDL regarding buoyant density, Sf rate, chemical composition, and behavior in electrophoresis. The results in the present study indicate that the accumulation of these Lps, which may include the previously-known Lp species such as the intermediate-density Lp or the remnant particles, is taking place in hemodialysis patients.
在接受长期血液透析治疗的尿毒症患者（血液透析患者）中，67%检测出严重异常的血清脂蛋白（Lp）谱，在聚丙烯酰胺凝胶电泳（PAG电泳）中呈现为宽中带模式（BMP）。研究发现，BMP归因于一系列离散的Lp的存在，这些Lp在浮力密度、Sf速率、化学组成和电泳行为方面介于β迁移的低密度脂蛋白（LDL）和前β迁移的极低密度脂蛋白（VLDL）之间。本研究结果表明，这些Lp（可能包括先前已知的Lp种类，如中密度Lp或残余颗粒）正在血液透析患者体内蓄积。
