Bouquot J E
Maxillofacial Center for Diagnostics & Research, Morgantown, W. Va., USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Sep;86(3):318-24. doi: 10.1016/s1079-2104(98)90179-2.
Much is known about the clinical appearance, biological behavior, and treatment of verrucous carcinoma of the oral cavity. However, the epidemiologic characteristics are completely unknown. This cancer is considered to be rare in Western cultures because it is not common in oral pathology biopsy services, but there is no epidemiologic evidence for this belief. To provide this evidence, 2 population-based incidence investigations were carried out, one in Rochester, Minn., and the other in the state of West Virginia. The results were as follows: the age-adjusted average annual incidence rate for oral verrucous carcinoma among Rochester residents was 0.1/100,000 person-years (0.2 for males, 0.0 for females), whereas the incidence rate for all intraoral carcinomas was 3.6/100,000 person-years (5.4 for males, 2.1 for females). Among men over 64 years of age, the incidence rate for verrucous carcinoma was increased to 3.2/100,000 person-years. Verrucous carcinoma was among the least common of the oral carcinomas in this population, representing only 3% of the total. The age-adjusted incidence rate for oral and pharyngeal verrucous carcinoma among West Virginia residents was somewhat greater, 0.3/100,000 person-years, and showed an even gender predilection (0.28 for males, 0.29 for females). The incidence rate for all oral/pharyngeal cancers in West Virginia was 8.8/100,000 person-years (13.4 for males, 5.7 for females), which was below the US average. The conclusion is that oral verrucous carcinoma is a rare tumor of older people, diagnosed in only 1 to 3 of every 1,000,000 persons each year.
人们对口腔疣状癌的临床表现、生物学行为及治疗方法了解甚多。然而，其流行病学特征却完全未知。在西方文化中，这种癌症被认为较为罕见，因为在口腔病理学活检服务中并不常见，但这一观点并无流行病学证据支持。为提供此类证据，开展了两项基于人群的发病率调查，一项在明尼苏达州罗切斯特市，另一项在西弗吉尼亚州。结果如下：罗切斯特市居民口腔疣状癌的年龄调整后平均年发病率为0.1/10万人口年（男性为0.2，女性为0.0），而所有口腔癌的发病率为3.6/10万人口年（男性为5.4，女性为2.1）。在64岁以上男性中，疣状癌发病率增至3.2/10万人口年。在该人群中，疣状癌是最不常见的口腔癌之一，仅占总数的3%。西弗吉尼亚州居民口腔和咽疣状癌的年龄调整发病率略高，为0.3/10万人口年，且性别倾向更为均衡（男性为0.28，女性为0.29）。西弗吉尼亚州所有口腔/咽癌的发病率为8.8/10万人口年（男性为13.4，女性为5.7），低于美国平均水平。结论是，口腔疣状癌是一种老年人的罕见肿瘤，每年每100万人中仅1至3人被诊断出。
