Nnko Kanankira A, Pima Raphael T, Baraka Calvin J, Chalya Daniel, Rwakatema Deogratius S, Mremi Alex
Department of Dental Surgery, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
SAGE Open Med Case Rep. 2024 May 22;12:2050313X241252344. doi: 10.1177/2050313X241252344. eCollection 2024.
Verrucous carcinoma is a well-recognized low-grade variant of squamous cell carcinoma. Cutaneous, oral, and anogenital forms exist. Exposure to persistent chronic irritation, inflammation, and repeated injury, as well as carcinogenic agents such as human papillomavirus infection, smoking, and alcohol use, are established risk factors. These neoplasms occur mostly in the oral cavity. The usual extraoral sites include the larynx, esophagus, genitals, and perineum. It is an extremely uncommon site of occurrence for the extraoral chin region. This unusual location makes the index case unique. Other uncommon sites reported include finger and foot. Case studies of verrucous carcinoma with huge tumor sizes are rare. Although it can be destructive locally, verrucous carcinoma typically does not spread to distant sites. Wide surgical excision with free margins is the most common treatment approach with a favorable prognosis. These tumors are likely to recur if they are incompletely excised, and recurred lesions tend to be more aggressive clinically as compared to their original counterparts. Herein, the authors describe a case of a huge oral verrucous carcinoma localized on the chin of a 43-year-old female patient. The clinical course, diagnostics, and proposed treatment have been discussed with the existing available literature.
疣状癌是一种公认的低级别鳞状细胞癌变体。存在皮肤、口腔和肛门生殖器等类型。暴露于持续性慢性刺激、炎症和反复损伤，以及致癌因素如人乳头瘤病毒感染、吸烟和饮酒，均为已明确的危险因素。这些肿瘤大多发生在口腔。常见的口腔外部位包括喉、食管、生殖器和会阴。口腔外的下巴区域是极其罕见的发病部位。这一不寻常的位置使得该病例具有独特性。其他报道的罕见部位包括手指和足部。肿瘤体积巨大的疣状癌病例研究很少见。尽管疣状癌可能在局部具有破坏性，但通常不会扩散至远处。切缘阴性的广泛手术切除是最常见的治疗方法，预后良好。如果切除不完全，这些肿瘤很可能复发，且复发的病变在临床上往往比原发病变更具侵袭性。在此，作者描述了一例发生在一名43岁女性患者下巴的巨大口腔疣状癌病例。已结合现有文献对该病例的临床病程、诊断及建议的治疗方法进行了讨论。
