Donadio C, Tramonti G, Lucchesi A, Auner I, Bianchi C
Unitá di Nefrologia, University of Pisa, Italy.
Ren Fail. 1998 Sep;20(5):703-6. doi: 10.3109/08860229809045166.
The aim of this study was to evaluate the early effects of high and low-osmolar contrast media on glomerular function in rats by using a new method based on the measurement of the urinary excretion of 99mTc-DTPA. Thirty-six Sprague-Dawley male rats were examined: nine rats were injected with diatrizoate (ionic high-osmolar contrast medium), nine rats with iohexol (nonionic low-osmolar contrast medium), and nine rats with saline as controls. The urinary excretion of 99mTc-DTPA in the first minutes after i.v. injection was assumed as an index of glomerular filtration rate. A lower urinary excretion of 99mTc-DTPA was found in rats treated with contrast media in comparison with control rats. This effect was more evident after diatrizoate but was statistically significant also after iohexol. In conclusion, a reduction in the glomerular filtration rate probably occurs in the first few minutes after contrast media administration. The measurement of urinary excretion of 99mTc-DTPA could be a simple method to detect acute glomerular effects due to contrast media or to other drugs.
本研究的目的是通过一种基于测量99mTc-DTPA尿排泄量的新方法，评估高渗和低渗造影剂对大鼠肾小球功能的早期影响。对36只雄性Sprague-Dawley大鼠进行了检查：9只大鼠注射了泛影葡胺（离子型高渗造影剂），9只大鼠注射了碘海醇（非离子型低渗造影剂），9只大鼠注射生理盐水作为对照。静脉注射后最初几分钟内99mTc-DTPA的尿排泄量被视为肾小球滤过率的指标。与对照大鼠相比，用造影剂处理的大鼠99mTc-DTPA的尿排泄量较低。泛影葡胺处理后这种效应更明显，但碘海醇处理后也具有统计学意义。总之，造影剂给药后的最初几分钟内可能会出现肾小球滤过率降低。测量99mTc-DTPA的尿排泄量可能是一种检测造影剂或其他药物引起的急性肾小球效应的简单方法。
