Thomsen H S, Dorph S, Mygind T, Nielsen H, Rygaard H, Larsen S, Skaarup P, Hemmingsen L, Holm J
Department of Diagnostic Radiology, Herlev Hospital, University of Copenhagen, Denmark.
Invest Radiol. 1988 Sep;23 Suppl 1:S164-7. doi: 10.1097/00004424-198809001-00027.
Urine profiles (albumin, glucose, N-acetyl-beta-D-glucosaminidase [NAG], lactate dehydrogenase [LDH], L-gamma-glutamyltransferase [GGT], sodium, and phosphate) were followed for seven days after intravenous (IV) administration of either diatrizoate, iohexol, ioxilan, or saline in 24 Wistar rats with a tubular dysfunction induced by IV sodium maleate. Ioxilan and saline had a similar effect on albumin excretion, iohexol had an intermediate effect, and diatrizoate increased it significantly from day 2 to day 7. Glucosuria was significantly greater after diatrizoate than after the nonionic contrast media (CM) or saline. Diatrizoate delayed normalization of enzymuria, whereas iohexol and ioxilan did not. None of the CM affected urinary sodium or phosphate excretion. It is concluded that Fanconi's syndrome is significantly aggravated only by diatrizoate.
在24只因静脉注射马来酸钠而导致肾小管功能障碍的Wistar大鼠中，静脉注射泛影酸盐、碘海醇、碘克沙醇或生理盐水后，连续七天监测尿液指标（白蛋白、葡萄糖、N-乙酰-β-D-氨基葡萄糖苷酶[NAG]、乳酸脱氢酶[LDH]、L-γ-谷氨酰转移酶[GGT]、钠和磷酸盐）。碘克沙醇和生理盐水对白蛋白排泄的影响相似，碘海醇的影响居中，而泛影酸盐从第2天到第7天显著增加白蛋白排泄。泛影酸盐后的糖尿显著高于非离子型造影剂（CM）或生理盐水后的糖尿。泛影酸盐延迟了酶尿的恢复正常，而碘海醇和碘克沙醇则没有。没有一种CM影响尿钠或磷酸盐排泄。结论是，只有泛影酸盐会显著加重范科尼综合征。
