Rosenwasser L J
Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, USA.
J Allergy Clin Immunol. 1998 Sep;102(3):344-50. doi: 10.1016/s0091-6749(98)70118-6.
The role of the polypeptide proinflammatory cytokine IL-1 family represents a group of proteins that have contrasting and synergistic biologic responses. IL-1alpha and beta and their precursor forms are heavily involved in the enhancement of inflammation and host defense. Within this family of gene products, there is also a naturally occurring receptor antagonist, IL-1ra, as well as a family of receptor proteins that have differential signaling functions and activities. The study of these proteins in human disease, including allergic disease and type 1 hypersensitivity responses, has led to a better understanding of the underlying general inflammation associated with these syndromes and has provided opportunities to look at new forms of intervention in allergic disease and asthma.
多肽促炎细胞因子白细胞介素-1（IL-1）家族的作用代表了一组具有相反和协同生物学反应的蛋白质。IL-1α和β及其前体形式在炎症增强和宿主防御中起重要作用。在这个基因产物家族中，还有一种天然存在的受体拮抗剂IL-1ra，以及一组具有不同信号传导功能和活性的受体蛋白。对这些蛋白质在人类疾病（包括过敏性疾病和I型超敏反应）中的研究，有助于更好地理解与这些综合征相关的潜在全身性炎症，并为研究过敏性疾病和哮喘的新干预形式提供了机会。
