Dold S, Heinrich J, Wichmann H E, Wjst M
GSF--Forschungszentrum fuer Umwelt und Gesundheit, Institut fuer Epidemiologie, Oberschleissheim, Germany.
J Allergy Clin Immunol. 1998 Sep;102(3):414-20. doi: 10.1016/s0091-6749(98)70129-0.
Helminthic infections induce an IL-4-dependent polyclonal stimulation of IgE synthetization. It is still unclear, however, what role helminths play in allergic sensitization.
We sought to determine the relationship between Ascaris-specific IgE and allergic sensitization in a nontropical country.
In 2 consecutive cross-sectional surveys in 1992-1993 and 1995-1996, data from school entrants (age range, 5 to 7 years), third graders (age range, 8 to 10 years), and sixth graders (age range, 11 to 14 years) were collected. The 2 younger groups were reexamined in the second survey. Data for about 2300 children, including a cohort of 700 subjects, were analyzed. Ascaris IgE and total and specific IgE to inhalant allergens were measured, and skin prick tests were performed. Information about asthma and allergic rhinitis was collected by a questionnaire.
Children who were Ascaris-IgE seropositive (>0.35 IU/mL) in both surveys had 10-fold higher levels of total IgE (451 IU/mL vs 45 IU/mL, P < .001) and higher prevalence rates of allergen-specific IgE seropositivity (56.3% vs 26.6%, P < .001). They also had a higher prevalence of allergic rhinitis (12.6% vs 3.7%, P < .001) and asthma (5.7% vs 1.6%, P < .05). In subjects who were Ascaris-seronegative in the first survey but seropositive in the second survey, total and specific IgE increased markedly. Sensitization to Dermatophagoides pteronyssinus increased nearly 3-fold in this group. In contrast, in children who became Ascaris-seronegative, total and specific IgE decreased.
Contact with low doses of helminthic antigen is associated with an increase of total and specific IgE production. Helminthic infections in East German children are not the cause for a low prevalence of allergies in the former East Germany.
蠕虫感染会引发白细胞介素-4依赖的免疫球蛋白E（IgE）合成多克隆刺激。然而，蠕虫在过敏致敏中所起的作用仍不清楚。
我们试图确定在一个非热带国家中，蛔虫特异性IgE与过敏致敏之间的关系。
在1992 - 1993年和1995 - 1996年连续进行的两次横断面调查中，收集了入学儿童（年龄范围5至7岁）、三年级学生（年龄范围8至10岁）和六年级学生（年龄范围11至14岁）的数据。较年幼的两个组在第二次调查中进行了重新检查。对约2300名儿童的数据进行了分析，其中包括一组700名受试者。检测了蛔虫IgE以及对吸入性过敏原的总IgE和特异性IgE，并进行了皮肤点刺试验。通过问卷调查收集了有关哮喘和过敏性鼻炎的信息。
在两次调查中蛔虫IgE血清阳性（>0.35 IU/mL）的儿童，其总IgE水平高出10倍（451 IU/mL对45 IU/mL，P <.001），且过敏原特异性IgE血清阳性患病率更高（56.3%对26.6%，P <.001）。他们的过敏性鼻炎患病率也更高（12.6%对3.7%，P <.001），哮喘患病率更高（5.7%对1.6%，P <.05）。在第一次调查中蛔虫血清阴性但第二次调查中血清阳性的受试者中，总IgE和特异性IgE显著增加。该组对屋尘螨的致敏率增加了近3倍。相比之下，在蛔虫血清转阴的儿童中，总IgE和特异性IgE下降。
接触低剂量的蠕虫抗原与总IgE和特异性IgE产生增加有关。东德儿童的蠕虫感染并非前东德地区过敏患病率低的原因。
