Taylor P M
Department of Clinical Veterinary Medicine, University of Cambridge.
Res Vet Sci. 1998 Jul-Aug;65(1):41-6. doi: 10.1016/s0034-5288(98)90025-x.
Some metabolic and endocrine effects of hypercapnia were studied in six ponies during halothane anaesthesia with neuromuscular blockade and controlled ventilation. Each was anaesthetised twice, once with a 40-minute-period of hypercapnia (10 kPa) and once when normocapnia (5.3 kPa) was maintained throughout two hour's anaesthesia. Routine cardiovascular monitoring was performed and blood samples were taken for assay of cortisol, insulin, glucose, lactate, muscle and liver enzymes and total protein. Anaesthesia induced hypotension and lacticacidaemia which were slightly ameliorated during hypercapnia. Hyperglycaemia was more marked during hypercapnia. Plasma cortisol increased in a similar manner in both groups and insulin tended to decrease. There were no major changes in the other variables measured. It was concluded that 40 minutes of hypercapnia during halothane anaesthesia in ponies may have improved perfusion and did not markedly alter the stress response.
在六匹小马身上，于氟烷麻醉、神经肌肉阻滞和控制通气的条件下，研究了高碳酸血症的一些代谢和内分泌效应。每匹马均接受两次麻醉，一次是在40分钟的高碳酸血症（10千帕）期间，另一次是在整个两小时麻醉过程中维持正常碳酸血症（5.3千帕）时。进行了常规心血管监测，并采集血样以测定皮质醇、胰岛素、葡萄糖、乳酸、肌肉和肝脏酶以及总蛋白。麻醉诱导了低血压和乳酸性酸中毒，在高碳酸血症期间略有改善。高碳酸血症期间高血糖更为明显。两组血浆皮质醇以相似方式升高，胰岛素则有下降趋势。所测其他变量无重大变化。得出的结论是，小马在氟烷麻醉期间40分钟的高碳酸血症可能改善了灌注，且未明显改变应激反应。
