Taylor P M
Department of Clinical Veterinary Medicine, University of Cambridge.
Res Vet Sci. 1998 Mar-Apr;64(2):133-40. doi: 10.1016/s0034-5288(98)90008-x.
The effects of surgery on endocrine and metabolic responses to anaesthesia were investigated in seven horses and eight ponies. They were anaesthetised twice and surgery was carried out on one occasion. Cardiorespiratory monitoring was performed and blood samples were taken for assay of cortisol, glucose, lactate, insulin, catecholamines and non-esterified fatty acids. All groups developed arterial hypotension which was more marked in the surgical groups where post operative pulse rate was also higher. Plasma cortisol concentration increased in all groups during anaesthesia but remained higher after surgery. Plasma lactate increased in all animals but was higher during surgery. Glucose, insulin and catecholamines did not change significantly during anaesthesia in the horses but NEFA decreased. Plasma glucose increased during anaesthesia in the ponies and was higher in the non-surgical groups. The study suggests that surgery has little additional effect on the stress response to halothane anaesthesia in Equidae.
在7匹马和8匹矮种马中研究了手术对麻醉时内分泌和代谢反应的影响。它们接受了两次麻醉，且在其中一次麻醉时进行了手术。进行了心肺监测，并采集血样以测定皮质醇、葡萄糖、乳酸、胰岛素、儿茶酚胺和非酯化脂肪酸。所有组均出现动脉低血压，在手术组中更为明显，手术组术后脉搏率也更高。麻醉期间所有组的血浆皮质醇浓度均升高，但术后仍保持较高水平。所有动物的血浆乳酸均升高，但在手术期间更高。马在麻醉期间葡萄糖、胰岛素和儿茶酚胺无显著变化，但非酯化脂肪酸减少。矮种马在麻醉期间血浆葡萄糖升高，且在非手术组中更高。该研究表明，手术对马科动物氟烷麻醉应激反应的额外影响很小。
