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[药物对类风湿关节炎手部功能的影响]

[The effect of drugs on hand function in rheumatoid arthritis].

作者信息

Curković B, Vlaić D, Babić-Naglić D

机构信息

Klinika za reumatske bolesti i rehabilitaciju KBC Rebro, Zagreb.

出版信息

Reumatizam. 1997;45(2):9-11.

PMID:9769722
Abstract

In 30 inpatients with diagnosis of rheumatoid arthritis according ACR criteria we evaluated efficacy of non steroid-antiinflammatory drugs (NSAIDs) and corticosteroids (CS) on pain, morning stiffness and grip strength. NSAIDs and combination of NSAIDs and CS showed statistically significant analgesic effect (P < 0.005). Combination of NSAIDs and CS statistically significant shortened morning stiffness comparing NSAIDs or CS as single drug. Grip strength didn't rise in any investigated group. This could be explained with long disease duration (11.69 years). Morning stiffness is symptom not related only to extracellular fluid cumulation in affected areas but also to other progressive and longlasting disease signs.

摘要

在30例根据美国风湿病学会(ACR)标准诊断为类风湿关节炎的住院患者中,我们评估了非甾体抗炎药(NSAIDs)和皮质类固醇(CS)对疼痛、晨僵和握力的疗效。NSAIDs以及NSAIDs与CS的联合用药显示出具有统计学意义的镇痛效果(P < 0.005)。与单独使用NSAIDs或CS相比,NSAIDs与CS联合用药在统计学上显著缩短了晨僵时间。在任何研究组中握力均未提高。这可能是由于病程较长(11.69年)所致。晨僵这一症状不仅与受累部位细胞外液的积聚有关,还与其他进行性和长期的疾病体征有关。

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