Alliel P M, Périn J P, Belliveau J, Pierig R, Nussbaum J L, Rieger F
Neurobiologie du développement normal et pathologique, IFM, Paris, France.
C R Acad Sci III. 1998 Jun;321(6):495-9. doi: 10.1016/s0764-4469(98)80781-6.
Multiple sclerosis (MS) is still of unknown origin and may involve autoimmune, genetic and viral components in a pathogenic sequence whose relative importance is yet to be determined. A peptide, isolated from the cerebrospinal fluid of MS patients, is similar to a fragment of the pol protein reverse transcriptase (RT) of the newly reported MSRV retrovirus. The 700 amino acid sequence of MSRV-RT is closely related to a novel human retroviral-like sequences. We also identified a gag-like sequence upstream of this human genomic RT-like sequence, which allowed us to identify altogether 4,000 nucleotides, possibly coding for an endogenous retroviruses. Homologous sequences found in other locations in the human genome seem to characterize a new family of retroviral endogenous sequences, which may be of relevance to multiple sclerosis.
多发性硬化症（MS）的病因仍不明，其发病过程可能涉及自身免疫、遗传和病毒因素，而这些因素的相对重要性尚待确定。从MS患者脑脊液中分离出的一种肽，与新报道的MSRV逆转录病毒的多聚蛋白逆转录酶（RT）片段相似。MSRV-RT的700个氨基酸序列与一种新的人类逆转录病毒样序列密切相关。我们还在该人类基因组RT样序列上游鉴定出一个gag样序列，据此总共鉴定出4000个核苷酸，可能编码一种内源性逆转录病毒。在人类基因组其他位置发现的同源序列似乎构成了一个新的逆转录病毒内源性序列家族，这可能与多发性硬化症有关。
