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培养的小鼠脾细胞中自发产生的自身反应性。I. 细胞毒性针对胚胎相关抗原的证据。

Autoreactivity developing spontaneously in cultured mouse spleen cells. I. Evidence that cytotoxicity is directed against embryo-associated antigen.

作者信息

Gorczynski R M

出版信息

Immunology. 1976 Oct;31(4):607-14.

PMID:977034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445354/
Abstract

We have investigated the ability of male-mouse spleen cells before and after culture in the absence of deliberate antigenic stimulation to show specific cytotoxicity to syngeneic embryo-fibroblast cells. The data suggest that cytotoxicity which develops spontaneously in such spleen cell cultures is directed primarily against embryo-associated antigens. Syngeneic Con-A-stimulated spleen cells, which, unlike fresh normal spleen cells, are also lysed by rabbit anti-mouse embryo antisera, are also a suitable target to demonstrate spontaneously developing cytotoxicity.

摘要

我们研究了雄性小鼠脾细胞在无特意抗原刺激情况下培养前后对同基因胚胎成纤维细胞显示特异性细胞毒性的能力。数据表明，在此类脾细胞培养物中自发产生的细胞毒性主要针对胚胎相关抗原。同基因伴刀豆球蛋白A刺激的脾细胞，与新鲜正常脾细胞不同，也会被兔抗小鼠胚胎抗血清裂解，也是用于证明自发产生细胞毒性的合适靶标。

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4
Autoreactivity developing spontaneously in cultured mouse spleen cells. II. Comparison of cytotoxicity of cultured male and female spleen cells.培养的小鼠脾细胞中自发产生的自身反应性。II. 培养的雄性和雌性脾细胞细胞毒性的比较。
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Response of tumour-related and normal lymphocytes to antigens on fibroblasts from embryos of varying age.肿瘤相关淋巴细胞和正常淋巴细胞对不同年龄胚胎成纤维细胞上抗原的反应。
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本文引用的文献

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An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.用于估计小鼠细胞毒素的51铬释放试验的扩展。
Transplantation. 1968 Sep;6(6):761-4. doi: 10.1097/00007890-196809000-00002.
2
Rejection of tumor allografts by mouse spleen cells sensitized in vitro.体外致敏的小鼠脾细胞对肿瘤同种异体移植物的排斥反应。
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4
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6
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Immunology. 1970 Apr;18(4):501-15.
7
Specific carcinoembryonic antigens of the human digestive system.人类消化系统的特异性癌胚抗原。
J Exp Med. 1965 Sep 1;122(3):467-81. doi: 10.1084/jem.122.3.467.
8
Embryonic antigen expression on experimental rat tumours.实验大鼠肿瘤上胚胎抗原的表达
Transplant Rev. 1974;20(0):77-99. doi: 10.1111/j.1600-065x.1974.tb00142.x.
9
Quantitative analysis of the 51Cr release cytotoxicity assay for cytotoxic lymphocytes.细胞毒性淋巴细胞的51铬释放细胞毒性试验的定量分析。
Cell Immunol. 1974 Nov;14(2):284-302. doi: 10.1016/0008-8749(74)90212-3.
10
Skin-reactive soluble antigen from intestinal cancer-cell-membranes and relationship to carcinoembryonic antigens.
Lancet. 1970 Jun 6;1(7658):1191-5. doi: 10.1016/s0140-6736(70)91784-8.

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