Pillar G, Etzioni A, Shahar E, Lavie P
Pediatrics Department A, Rambam Medical Center, Haifa, Israel.
Arch Dis Child. 1998 Jul;79(1):63-4. doi: 10.1136/adc.79.1.63.
An institutionalised 13 year old girl with psychomotor retardation suffered from an irregular sleep-wake pattern. Multiple measurements of urinary sulphatoxy-melatonin (aMT6) concentrations were abnormally low, without any significant day-night differences. Administration of exogenous melatonin (3 mg) at 18:00 resulted in increased nocturnal urinary aMT6 concentrations and improvements in her sleep-wake pattern. Melatonin may help disabled children suffering from sleep disorders.
一名患有精神运动发育迟缓的13岁寄养女童存在不规律的睡眠-觉醒模式。多次测量尿中硫酸氧基褪黑素（aMT6）浓度均异常低，且无明显的昼夜差异。18:00给予外源性褪黑素（3毫克）后，夜间尿aMT6浓度升高，睡眠-觉醒模式得到改善。褪黑素可能有助于患有睡眠障碍的残疾儿童。
