Adams W M, Miller P E, Vail D M, Forrest L J, MacEwen E G
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 53706, USA.
Vet Radiol Ultrasound. 1998 Sep-Oct;39(5):475-81. doi: 10.1111/j.1740-8261.1998.tb01637.x.
Tumor and normal tissue response was assessed in 21 dogs with malignant nasal tumors given 42 Gy cobalt radiation in 9 or 10 fractions over 11 to 13 days. Local tumor/clinical relapse recurred in 68% of dogs, with a median relapse free interval (RFI) of 270 days. Median survival was 428 days. One year survival for all dogs was 60%. RFI and survival times are better than, or similar to, previous reports of dogs treated with radiotherapy only. Acute radiation effects were severe in one dog. Late effects were severe in six of 15 dogs (40%) with durable tumor control. Late effects included bilateral blindness (3), osteoradionecrosis (3), and seizures (1). These six dogs had a median survival of 705 days. Loss of vision occurred in at least one eye in nine dogs (47%). Tumor staging based on CT findings was predictive for survival duration. Tumor histology was not predictive of outcome. Labrador Retrievers were significantly over-represented. Despite comparable or improved tumor control and survival times provided by this accelerated protocol, relative to other radiotherapy reports, local failure remains the major cause of death, and late radiation effects can be severe in dogs with durable tumor control.
对21只患有恶性鼻肿瘤的犬进行了评估，这些犬在11至13天内分9或10次接受了42 Gy的钴辐射。68%的犬出现局部肿瘤/临床复发，无复发间隔（RFI）的中位数为270天。中位生存期为428天。所有犬的一年生存率为60%。RFI和生存时间优于或类似于之前仅接受放疗的犬的报道。1只犬出现严重的急性辐射效应。在15只实现持久肿瘤控制的犬中，6只（40%）出现严重的晚期效应。晚期效应包括双侧失明（3只）、放射性骨坏死（3只）和癫痫发作（1只）。这6只犬的中位生存期为705天。9只犬（47%）至少一只眼睛出现视力丧失。基于CT结果的肿瘤分期可预测生存时间。肿瘤组织学不能预测预后。拉布拉多寻回犬的比例显著过高。尽管相对于其他放疗报道，这种加速方案提供了相当或更好的肿瘤控制和生存时间，但局部失败仍然是主要的死亡原因，并且在实现持久肿瘤控制的犬中，晚期辐射效应可能很严重。
