Loddo Pietro, Schiavo Luca, Dobson Jane, Marcinowska Ola
Queen's Veterinary School Hospital, Cambridge University, Cambridge, UK.
Department of Oncology Service, Davies Veterinary Specialist, Higham, UK.
Vet Radiol Ultrasound. 2025 Jan;66(1):e70000. doi: 10.1111/vru.70000.
Primary frontal sinus squamous cell carcinoma (PFSSCC) represents a rare disease in dogs, and there is a general paucity of information in the current veterinary literature regarding its presentation and response to radiation therapy. The objective of this retrospective observational study was to describe a series of dogs diagnosed with PFSSCC and report their response to radiation therapy. Medical records of dogs with a diagnosis of PFSSCC were reviewed. Data collected included signalment, presenting complaint, clinicopathologic and diagnostic imaging findings, treatment, therapeutic response, and date of death or last follow-up. Eight cases of PFSSCC in dogs were treated with radiation therapy at the authors' institution. Three of these dogs were treated with coarse-fractionated radiation therapy. One dog was euthanized due to an unrelated cause 36 months after completing the radiation therapy. The second and third dogs survived 18 and 3 months, respectively, from the end of treatment to death due to PFSCC. Five further dogs were treated with a more fractionated protocol (Monday-Wednesday-Friday schedule). The median survival time for all patients was 7.5 months (range 2-36 months). Despite the small number of cases and variation in the radiation protocols used, the treatment outcomes in these eight dogs suggest that radiation therapy is potentially a viable treatment option for dogs with PFSSCC and that coarse fractionation might be an appropriate approach if more finely fractionated protocols are not possible.
原发性额窦鳞状细胞癌（PFSSCC）在犬类中是一种罕见疾病，目前兽医文献中关于其临床表现及对放射治疗反应的信息普遍匮乏。这项回顾性观察研究的目的是描述一系列被诊断为PFSSCC的犬类，并报告它们对放射治疗的反应。对诊断为PFSSCC的犬类的病历进行了回顾。收集的数据包括特征、就诊主诉、临床病理和诊断成像结果、治疗、治疗反应以及死亡日期或最后随访日期。作者所在机构对8例犬类PFSSCC进行了放射治疗。其中3只犬接受了大分割放射治疗。1只犬在完成放射治疗36个月后因无关原因实施安乐死。第二只和第三只犬从治疗结束到因PFSSCC死亡分别存活了18个月和3个月。另外5只犬采用了更精细的方案（周一至周三至周五日程）进行治疗。所有患者的中位生存时间为7.5个月（范围2 - 36个月）。尽管病例数量较少且所使用的放射治疗方案存在差异，但这8只犬的治疗结果表明，放射治疗可能是患有PFSSCC犬类的一种可行治疗选择，并且如果无法采用更精细的分割方案，大分割可能是一种合适的方法。
