Ferrari G, Cappelli V, Cariani T
Int J Vitam Nutr Res. 1976;46(3):303-9.
Blood pyruvate and free and phosphorylated thiamin contents of liver and brain were measured in pigeons during diatary thiamin deficiency. Neurologic signs (opisthotonus and ataxia) appeared in the course of thiamin deficiency or did not appear at all during the entire athiaminosis period. As compared to respective controls, which never exhibited any neurologic abnormalities in spite of thiamin deficiency, the symptomatic animals had a higher pyruvate level in blood and a significantly lower phosphorylated thiamin content in both liver and brain. A hypothesis on relationship between phosphorylated thiamin content of liver and brain and occurence of nervous symptoms was expressed.
在鸽子的饮食性硫胺素缺乏期间，测量了其血液丙酮酸以及肝脏和大脑中游离和磷酸化硫胺素的含量。在硫胺素缺乏过程中出现了神经症状（角弓反张和共济失调），或者在整个无硫胺素血症期间根本未出现。与各自的对照组相比，尽管对照组存在硫胺素缺乏，但从未表现出任何神经异常，有症状的动物血液中的丙酮酸水平较高，肝脏和大脑中的磷酸化硫胺素含量显著较低。提出了关于肝脏和大脑中磷酸化硫胺素含量与神经症状发生之间关系的假说。
