Dai H, Jin H, He J
Affiliated Obstetrics and Gynecology Hospital, Zhejiang Medical University, Hangzhou.
Zhonghua Fu Chan Ke Za Zhi. 1997 Dec;32(12):728-31.
To identify the influence of the increased level of serum cholyglycine (CG) on lipid metabolism and hemorrheology in patients with intrahepatic cholestasis during pregnancy (ICP).
The concentrations of serum CG, total cholesterol (CH), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), high shear and low shear of blood specific viscosity (HS and LS), plasma specific viscosity (PV) and hematocrit (HCT) were measured in 68 cases of primiparas with single pregnancy and 30 healthy nonpregnant women respectively. The group of ICP was composed of 35 cases with CG > 6 mumol/L, the group of normal pregnancy, 33 cases with CG < 6 mumol/L.
The means of CG and the lipidic parameters in the two pregnant groups were significantly higher than those in the non-pregnancy group (P < 0.02-0.001) except the means of HDL-C between the groups of ICP and non-pregnancy. The levels of LDL-C, LDL-C/HDL-C, LS, PV and HCT in the ICP were significantly higher than those in the normal pregnancy group (P < 0.02-0.001).
There are significant changes of lipid metabolism and hemorrheology in patients with ICP. However, these changes could be corrected after pregnancy termination, when the level of serum CG returned to normal. The results suggest that the pathophysiologic changes of ICP are associated with increased level of serum CG.
探讨血清甘氨胆酸（CG）水平升高对妊娠期肝内胆汁淤积症（ICP）患者脂质代谢及血液流变学的影响。
分别测定68例单胎初产妇和30例健康未孕妇女血清CG、总胆固醇（CH）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、高切和低切全血比黏度（HS和LS）、血浆比黏度（PV）及血细胞比容（HCT）。ICP组35例，CG>6 μmol/L；正常妊娠组33例，CG<6 μmol/L。
除ICP组与未孕组HDL-C均值外，两组孕妇CG及脂质参数均值均显著高于未孕组（P<0.020.001）。ICP组LDL-C、LDL-C/HDL-C、LS、PV及HCT水平显著高于正常妊娠组（P<0.020.001）。
ICP患者脂质代谢及血液流变学有显著变化。然而，终止妊娠血清CG水平恢复正常后，这些变化可得到纠正。结果提示，ICP的病理生理变化与血清CG水平升高有关。
