Jiang X L, Xu L N
Yao Xue Xue Bao. 1989;24(4):251-4.
Puerarin is one of the main active principles of Radix Puerarin. In the present paper, the effect of puerarin iv or topical treatment on adrenaline induced mesenteric microcirculatory disturbance in mice was studied and compared with papaverine. The arteriole diameter (D) and blood flow velocity (V) of arterioles were observed and recorded by the vitalvideo microscope and the digit blood flow velocity apparatus, and blood flow (Q) was calculated as Q = pi (D/2)2.V. Results indicate that puerarin applied locally, either before or after the topical treatment with adrenaline on arteriole, impeded the constriction and increased the decreased blood flow at 1,3,5,10, 20 minutes (P less than 0.01). A similar response was observed with papaverine. When puerarin and papaverin were given intravenously to mice at the dosages of 52 and 10 mg/kg respectively, both showed protective effects on the microcirculatory disturbance induced by adrenaline administered locally 5 min later. The effect of puerarin was shown to be more potent than that of papaverine. Since the toxicity of puerarin is very low, puerarin might be superior to papaverine for treatment of microcirculatory disturbance.
葛根素是葛根的主要活性成分之一。本文研究了葛根素静脉注射或局部给药对肾上腺素所致小鼠肠系膜微循环障碍的影响，并与罂粟碱进行了比较。通过活体显微镜和数字血流速度仪观察并记录微动脉的管径（D）和血流速度（V），血流（Q）按Q = π（D/2）²·V计算。结果表明，在局部应用肾上腺素前后，局部给予葛根素均能抑制微动脉收缩，并使1、3、5、10、20分钟时降低的血流增加（P < 0.01）。罂粟碱也有类似反应。当分别以52和10 mg/kg的剂量给小鼠静脉注射葛根素和罂粟碱时，二者对5分钟后局部给予肾上腺素所致的微循环障碍均有保护作用。结果显示葛根素的作用比罂粟碱更强。由于葛根素的毒性很低，在治疗微循环障碍方面，葛根素可能优于罂粟碱。
