Mann J J
Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA.
J ECT. 1998 Sep;14(3):172-80.
This article reviews the major neurobiologic effects of electroconvulsive therapy (ECT) implicated in its antidepressant actions. These effects are organized into three main groups: (1) the action of ECT on the monoamine neurotransmitter system, norepinephrine, serotonin, and dopamine; (2) the neurotrophic action of ECT; and (3) the anticonvulsant effect of ECT. This review emphasizes clinical studies, but relevant animal studies are used to infer more details about changes in neurotransmitter turnover, peptides, and changes in gene expression. There are significant differences in the actions of ECT compared with antidepressant medications, for example, on monoaminergic systems, which may explain why ECT is such an effective antidepressant.
本文综述了电休克治疗（ECT）抗抑郁作用所涉及的主要神经生物学效应。这些效应主要分为三组：（1）ECT对单胺类神经递质系统（去甲肾上腺素、5-羟色胺和多巴胺）的作用；（2）ECT的神经营养作用；（3）ECT的抗惊厥作用。本综述重点关注临床研究，但也引用了相关动物研究，以推断神经递质周转率、肽类以及基因表达变化的更多细节。ECT与抗抑郁药物的作用存在显著差异，例如在单胺能系统方面，这可能解释了ECT为何是一种如此有效的抗抑郁药。
