Ori C
Istituto di Anestesiologia e Rianimazione, Università degli Studi, Padova.
Minerva Anestesiol. 1998 May;64(5):235-8.
Hyponatremia is a common feature after subarachnoid hemorrhage. Hyponatremia is complex in its origin because different neuroendocrine disturbances are involved: elements of inappropriate secretion of ADH, cerebral salt wasting, and blunted response of the reninangiotensin-aldosterone system may occur simultaneously. Hyponatremia is accompanied by hypovolemia which implies a major risk for vasospasm and cerebral infarction. Hyponatremia itself might cause cerebral edema and intracranial hypertension. Fluid restriction is therefore contraindicated in hyponatremia following subarachnoid hemorrhage because of the negative impact on intravascular volume. On the contrary, replacement of both volume and sodium should be vigorously accomplished.
低钠血症是蛛网膜下腔出血后的常见特征。低钠血症的病因复杂,因为涉及不同的神经内分泌紊乱:抗利尿激素分泌不当、脑性盐耗综合征以及肾素 - 血管紧张素 - 醛固酮系统反应迟钝等因素可能同时出现。低钠血症伴有血容量减少,这意味着有发生血管痉挛和脑梗死的重大风险。低钠血症本身可能导致脑水肿和颅内高压。因此,蛛网膜下腔出血后出现低钠血症时,由于对血管内容量有负面影响,限制液体摄入是禁忌的。相反,应积极补充血容量和钠。