Ris L, Godaux E
Laboratory of Neurosciences, University of Mons-Hainaut, Mons, Belgium.
Neurosci Lett. 1998 Sep 4;253(2):131-4. doi: 10.1016/s0304-3940(98)00631-4.
Single unit activity of second-order vestibular neurons was recorded in alert guinea pigs. Here, we compared the spike discharge regularity (measured by calculating the coefficient of variation (CV)) of neurons from control animals with those from animals labyrinthectomized 1 week before. The mean CV (+/-SD) were the same in both groups (0.72+/-0.43 vs. 0.70+/-0.39). Furthermore, in both groups, the CV was related to the resting rate (RR) according to the same law (CV = 4/square root of RR). Because the discharge of a neuron is more regular when it is due to a pacemaker activity than when it is due to the synaptic drive, we conclude that restoration in the firing rate after labyrinthectomy is due to increase in the synaptic drive rather than to increase in the (intrinsic) pacemaker activity.
在清醒的豚鼠中记录了二级前庭神经元的单单位活动。在此，我们比较了来自对照动物的神经元与1周前接受迷路切除的动物的神经元的放电规律性（通过计算变异系数（CV）来测量）。两组的平均CV（±标准差）相同（0.72±0.43对0.70±0.39）。此外，在两组中，CV与静息率（RR）遵循相同规律相关（CV = 4/√RR）。因为当神经元放电是由起搏器活动引起时比由突触驱动引起时更具规律性，所以我们得出结论，迷路切除术后放电率的恢复是由于突触驱动的增加而非（内在）起搏器活动的增加。
