Ris Laurence, Hachemaoui Mohammed, Godaux Emile
Laboratoire de Neurobiologie des Réseaux Sensorimoteurs, CNRS ESA 7060, Universités Paris 5 et Paris 7, Centre Universitaire des Saints-Pères, 75270 Paris Cédex 06, France.
Neuroreport. 2002 Oct 28;13(15):1875-9. doi: 10.1097/00001756-200210280-00009.
In the guinea pig, in the absence of any stimulation, all the neurons of the vestibular nuclei are tonically firing. After an ipsilateral labyrinthectomy, these neurons first cease to fire but recover their previous discharge in 7 days. Here, we tested whether a modification of the spike generator, the process transforming synaptic currents into spike patterns, could be a factor underlying this restoration. For this purpose, we studied the firing rate responses of neurons of the medial vestibular nucleus in brain stem slices to intracellularly injected currents. We conclude that although labyrinthectomy induces some plastic changes in the excitability of the neurons of the medial vestibular nucleus, these changes do not underlie the restoration of activity which occurs in these neurons when they are deprived of their labyrinthine input.
在豚鼠中，在没有任何刺激的情况下，前庭核的所有神经元都在持续放电。同侧迷路切除术后，这些神经元首先停止放电，但在7天内恢复到之前的放电状态。在此，我们测试了动作电位发生器（即将突触电流转化为动作电位模式的过程）的改变是否可能是这种恢复的潜在因素。为此，我们研究了脑干切片中内侧前庭核神经元对细胞内注入电流的放电频率反应。我们得出结论，尽管迷路切除术在内侧前庭核神经元的兴奋性上诱导了一些可塑性变化，但这些变化并不是这些神经元在失去迷路输入时发生的活动恢复的基础。
